The researchers developed a calculation model for five types of infections based on data from the European Antimicrobial Resistance Surveillance Network (EARS).
For 2015, they calculated the number of infected persons at 671,689 and the number of deaths attributable to multidrug resistant bacteria at 33,110.
The effect is "comparable to the cumulative effect of influenza, tuberculosis and AIDS virus" during the same period, according to the authors.
The majority of deaths affect children under the age of 12 and people over 65 years of age.
The effect in terms of mortality is higher in Italy and Greece (the former concentrates more than one third of the death rate), according to the study.
The medical sector constantly warns of the risk of excessive or inappropriate consumption of antibiotics, which makes the bacteria resistant to them.
An Australian law highlighted in September the dangerous spread of bacteria resistant to all existing drugs, Staphylococcus epidermidis, which can cause serious diseases and even deaths and are related to methicillin-resistant Staphylococcus aureus (MRSA).
Of the 671,689 infections caused by a multidrug resistant bacterium 2015, approximately two thirds were withdrawn in the hospital setting.
Researchers emphasize "urgent consideration of antibiotic resistance as an important health factor" and "the need to design alternative treatments for patients with other diseases that are more vulnerable due to the deterioration of their immune system or their age."