Bournemouth striker Callum Wilson has received his first leading international call for England's game against the United States and Croatia.
Former England captain and record scorer Wayne Rooney has been included only for US friendship.
Everton centerback Michael Keane is withdrawn to the squad for the first time in a year.
England is playing the United States on Thursday, November 15 before hosting Croatia in the Nations League the following Sunday.
Midfielder Parts Alli and Jesse Lingard return after missing the final round of international injury, with Mason Mount and James Maddison leaving out of the squad.
Winger Jadon Sancho, 18, retains his place while Unique Trio – Brighton center back Lewis Dunk, Fulham goalkeeper Marcus Bettinelli and Southampton goalkeeper Alex McCarthy – have been called again.
Rooney, 33, will win his 120th and last England cap as he comes out of an international retirement game against the United States in Wembley who will collect money for the Wayne Rooney Foundation.
DC United forward, who has made 53 international goals and made his latest international appearance in a 3-0 victory over Scotland in November 2016, will be used as a second half replacement.
England manager Gareth Southgate said discussions about hiring Rooney began 12 months ago and the player denied the opportunity to be honored before the World Cup.
"I can still look at the future with the troop we have chosen, but we've talked a lot about the history of the shirt," he said. "I think all players respect Wayne's contributions and deserve the best possible reconciliation."
Former England Under 21-wiser Wilson has been rewarded for his form this season and points out six Premier League goals.
"He is a threat when it comes to driving in for defense," said Southgate. He has been involved in either scoring or assisting with a large number of goals this season so it's a good time for us to take a look at him and see how he fits into what we do and for him to feel of working with the senior team. "
Is Rooney's return devaluing England hats?
England's record appearance is former goalkeeper Peter Shilton, with 125 appearances for his country.
He said hats would not be "presented as presents" and that he was "surprised" Southgate had allowed Rooney to include.
"The value of caps is very hard to be accurate," said Southgate.
"You can continue with two minutes to go because you need a change – I've played when we've changed the whole team at half-time.
"I hope Wayne gets the right answer, because he has been a huge servant.
"We are a weird country by regretting the fact that we have not achieved as much as we want, and then we have a player who should be kept to the highest extent and we motivate to include him.
"I'm sure the audience will give him the treatment he deserves."
England squad in its entirety: Trent Alexander-Arnold (Liverpool), Dele Alli (Tottenham), Ross Barkley (Chelsea), Marcus Bettinelli (Fulham), Jack Butland (Stoke City), Ben Chilwell (Leicester City), Fabian Delph (Manchester City), Eric Dier Tottenham ), Lewis Dunk (Brighton), Joe Gomez (Liverpool), Jordan Henderson (Liverpool), Harry Kane (Tottenham), Michael Keane (Everton), Jesse Lingard (Manchester United), Ruben Loftus Cheek Wayne Rooney (DC United) Jadon Sancho (Borussia Dortmund), Luke Shaw (Manchester United), Raheem Sterling (Manchester City), John Stones (Manchester City), Jordan Pickford (Everton), Marcus Rashford, Kieran Trippier (Tottenham), Kyle Walker , Danny Welbeck (Arsenal), Callum Wilson (Bournemouth), Harry Winks (Tottenham).