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Broccoli compounds can stop the development of cancerous tumors

Mexico on May 17 (Notimex) .- A group of international researchers found that existing compounds in broccoli and noise sprouts can block cancer tumors.

Pier Paolo Pandolfi, a graduate of medicine and pathology at Harvard Medical School and leader of the study identified a compound called I3C, which develops inside the body and prevents the development of tumors.

According to information from the educational institution, the work was based on the function of a cancer suppressor gene called PTEN, one of the major tumor suppressors in the history of the genetic disease.

According to Harvard University, this gene is usually attacked by cancers, which attempt to eliminate, mutate or inactivate them.

The specialists, who used human cells and mice to develop prostate cancer, found that an enzyme called WWP1 that promotes cancer growth was very important to interfere with PTEN function.

The study, published in the journal "Science", would enable the development of drugs based on the suppression of WWP1 and the release of PTEN to achieve results.

It can also help people with a genetic deficiency of PTEN that make them prone to developing cancer, and cause developmental defects that can lead to intellectual disability or mental illness.

"We believe that this class of drugs can be very important for human health beyond cancer," Pandolfi said.

The protective compound of PTEN, I3C, is found in cruciferous vegetables such as broccoli, breast sprouts, cabbage and cauliflower.

The specialist emphasized that it is also necessary to carry out an additional assay to study appropriate doses and undesirable effects of I3C supplements.

The work was developed at the Cancer Center and Cancer Research Institute at Beth Israel Deaconess Medical Center by Pandolfi and his team, representatives of the US, Taiwan, China, Italy, Australia and India and supported by the National Institutes of Health.

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